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Pharmaceutical Gel Capsule Materials
Enhance your oral gel capsule formulations with high quality ingredients
Consumers prefer gel capsules over other dosage forms making the development of medicines in this format more relevant than ever. CARBOWAX™ SENTRY™ Liquid Polyethylene Glycol (PEG) is a pharmaceutical excipient which can be used in the manufacturing of gel capsules as hydrophilic fillers aiding solubilization of active pharmaceutical ingredients (API). PEG also acts as plasticizer in the coating of the gel capsules. Our liquid PEG excipients enable a reduced risk of cross linking and contain lower impurity profiles, all while meeting the highest regulatory standards.
Solutions for gel capsule applications
Available low aldehyde grades
Reduce the risk of cross linking
Low aldehyde PEG grades help minimize the risk of cross linking in the gel capsule shell.
Recommended grades:
- Low aldehyde and low ethylene glycol PEG 300
- Low aldehyde and low ethylene glycol PEG 400
- Low aldehyde and low ethylene glycol PEG 600
To maintain low ethylene glycol levels throughout processing, we recommend following Dow’s handling guidance.
Improve solubility in gel capsule formulation
Our low molecular weight carriers and fillers enhance gel capsule formulation by improving solubility of active pharmaceutical ingredients.
Recommended grades:
- 5-50% CARBOWAX™ SENTRY™ PEG 300
- 5-50% CARBOWAX™ SENTRY™ PEG 400
- 5-50% CARBOWAX™ SENTRY™ PEG 600
Enhance the elasticity of capsule shells
Our broad range of plasticizers help improve the elasticity of the soft gel capsule shells.
Recommended grades:
- 5-30% CARBOWAX™ SENTRY™ PEG 300
- 5-30% CARBOWAX™ SENTRY™ PEG 400
- 5-50% CARBOWAX™ SENTRY™ PEG 600
- 5-30% CARBOWAX™ SENTRY™ PEG 1000
- 5-30% CARBOWAX™ SENTRY™ PEG 1450
The optimal PEG quantity depends on your formulation components. Contact a Dow representative for assistance in defining your ideal dosage.
Reduce degradation risks
VERSENE™ NA Edetate Disodium is a partially neutralized salt of EDTA in dry form, making it suitable for pharmaceutical formulations. Operational life of in-process liquids, including coatings, can be extended with the use of VERSENE NA. Active ingredients are often sensitive to oxidation or chemical attacks, either through direct attack or catalysis by transition metal ions which can occur during processing or storage. The addition of VERSENE NA helps to minimize these effects.
Recommended grades:
- – 1% VERSENE™ NA Edetate Disodium
CARBOWAX™ SENTRY™ PEG Solubility Chart
Find the right solubilizer for your poorly soluble or sensitive drugs with this useful resource that compares water to PEG solubility.
Addressing Residual Solvent Limits
Discover our customized grades of liquid PEGs enabling lower levels of ethylene glycols in your formulations.
VERSENE™ NA Chelating Agent
Protect your pharmaceutical preparations with this effective stabilizer and preservative.
What are the benefits of using CARBOWAX™ SENTRY™ Polyethylene Glycols (PEGs) in gel capsules?
A trusted solubilizer for poorly water-soluble Class II & Class IV APIs.
Selecting our low aldehydes grades helps reduce the risk of cross linking of the shell.
Allowing more consistent manufacturing and longer shelf-life of drugs.
Lowering the Ethylene Glycol (EG) levels in your formulation.
Offering regional regulatory and technical support for pharmaceutical applications.
We are open to collaborate and support in solving any challenges you may have.