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  1. Home
  2. Healthcare and Hygiene
  3. Reliable Pharmaceutical Solutions
  4. Enabling Pharmaceutical Gel Capsule Formulations

Enabling Pharmaceutical Gel Capsule Formulations

Enhance your oral formulations with high quality ingredients

Consumers prefer gelatin capsules over other dosage forms, so the development of drugs in this form is more relevant than ever.

CARBOWAX™ SENTRY™ LPEG and MPEGs are pharmaceutical excipients which can be used in the manufacturing of capsules as hydrophilic fillers for solubilization of the Active Pharmaceutical Ingredient (API), but also as plasticizer in the coating of the gelatin capsules.

CARBOWAX™ SENTRY™ Polyethylene Glycols (PEGs) have a long history of use in capsule formulations because they meet all compendial requirements and:

  • Our low molecular weight PEGs can facilitate formulation of gelatin capsules when working with poorly soluble APIs
  • When selecting our low aldehydes grades, it can help you reduce the risk of cross linking of the shell
  • Our grades have low impurity profiles allowing more consistent manufacturing and longer shelf-life of your drugs
  • It can help you improve your residual solvent profile by lowering the Ethylene Glycol (EG) levels in your formulation.

Our PEGs meet USP-NF and EP monographs required for pharmaceutical applications, and we offer regional regulatory and technical support.
 

Available Low Aldehyde grades
Minimize cross linking of the gelatin shell
  • Low aldehyde and low ethylene glycol PEG 300
  • Low aldehyde and low ethylene glycol PEG 400
  • Low aldehyde and low ethylene glycol PEG 600
Maintain low EG levels throughout processing by following Dow’s simple handling guidance
Carriers/Filler
Improve the solubility of poorly soluble APIs by using
  • 5-50% CARBOWAX™ SENTRY™ PEG 300
  • 5-50% CARBOWAX™ SENTRY™ PEG 400
  • 5-50% CARBOWAX™ SENTRY™ PEG 600
Example poorly soluble APIs: Acyclovir
Plasticizers
Improve the elasticity of the soft gelatin capsule shells
  • 5-30% CARBOWAX™ SENTRY™ PEG 300
  • 5-30% CARBOWAX™ SENTRY™ PEG 400
  • 5-50% CARBOWAX™ SENTRY™ PEG 600
  • 5-30% CARBOWAX™ SENTRY™ PEG 1000
  • 5-30% CARBOWAX™ SENTRY™ PEG 1450
The optimum quantity of the PEG in the formulation depends on the rest of the components. We recommend formulators to calculate their optimum dosage, and we are here to give guidance
Stabilizers
Reduce degradation risks
  • 0.1 – 1% VERSENE™ NA Edetate Disodium
EDTA prevents chemical degradation of oxidation sensitive drugs which process is catalyzed by free metals in gelatin, such as iron.

 

Resources

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Contact us to discuss about gelatin capsules challenges

Do you want to learn more about Dow Life Sciences portfolio? Contact us and let’s have a chat! We are open to collaborate and support in solving any challenges you may have.
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CARBOWAX™ SENTRY™ Product Selection guide

Provides a brief explanation of polyethylene glycols, examines different grades and explains the benefits of choosing Dow as your supplier.