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Pharmaceutical Heat Management
Precision Thermal Control for end-to-end Pharmaceutical Manufacturing across modalities from synthesis to fill-finish
We provide a broad portfolio of heat transfer fluids and application expertise that enables precise temperature control across chemical synthesis and fermentation for APIs and precursors, lyophilization, vaccine production, and reaction control.
Backed by decades of thermal science, Dow’s portfolio helps improve process reliability, product quality, and operational efficiency in highly controlled pharmaceutical environments.
Solutions Across Applications
Enhancing Lyophilization Performance
Lyophilization (freeze‑drying) is a key step in sterile fill finish pharmaceutical manufacturing. It removes water from frozen drug products under low temperature and vacuum conditions to maintain structural stability and efficacy, especially for sensitive biologics found in vaccines, monoclonal antibodies, and protein-based therapies.
Silicone fluids enable this process, effective with wide operating temperature ranges, for precise control of manufacturing steps.
Dow provides free annual analysis to qualifying customers.
Benefits
- Excellent thermal stability and reliable low‑temperature performance (e.g., SYLTHERM™ XLT Heat Transfer Fluid used at –100°C and heated up to +260°C).
- Silicone fluids are not water diluted, have very low toxicity, and odor. In the United States, are not listed as reportable under SARA Title III, Section 313.
- Silicone fluids are biostatic, noncorrosive, and show better resistance to oxidation when compared to a glycol-based alternative.
- Silicones are used for low temperature conditions due to their very low viscosity; glycols may have viscosity increase so much so that the application is not viable.
- Silicone fluids offer superior fluid lifetime and performance vs. glycol-based fluids.
Explore Highlighted Products
SYLTHERM™ 800 Stabilized Heat Transfer Fluid
A specially formulated, highly stable, long-lasting silicone polymer designed for high-temperature liquid phase heat transfer fluid applications, with a recommended operating temperature range of -40°F to 750°F (-40°C to 400°C).
SYLTHERM™ XLT Heat Transfer Fluid
A specially formulated, high-performance silicone polymer designed for use as a low temperature, liquid-phase heat transfer fluid, offering outstanding low temperature heat transfer and pumpability.
SYLTHERM™ HF Heat Transfer Fluid
A specially formulated, high performance silicone polymer designed for use as a low temperature, liquid phase heat transfer fluid, with a recommended use temperature range of -100°F to 500°F (-73°C to 260°C).
Optimizing Fermentation with Reliable Heat Transfer Fluids
Propylene glycol-based heat management fluids are used in fermentation processes to manufacture biological modalities such as peptides, recombinant proteins and antibodies, and mRNA and API precursors for actives in vaccines, GLP-1RA, and other therapies.
We offer free analysis services for DOWFROST™ HD Heat Transfer Fluids (minimum volume of 250 gallons to qualify).
Benefits
- Tight temperature control for exothermic bioprocesses to maximize fermentation yields.
- Freeze and corrosion protection in closed‑loop systems.
- Compatibility with CIP/SIP and stainless‑steel equipment.
- DOWFROST™ Heat Transfer Fluids are NSF HT-1 certified.
Explore Highlighted Products
DOWFROST™ Heat Transfer Fluid
A formulation of 96% food grade propylene glycol plus food grade corrosion inhibitors. Enables freeze protection to below -50°C (-60°F) and burst protection to below -73°C (-100°F). It is made entirely from food grade raw materials conforming to FDA CFR 21 and NSF guidelines.
DOWFROST™ HD Heat Transfer Fluid Dyed
A formulation of 94.0% propylene glycol and a specially designed package of industrial corrosion inhibitors. The fluid is dyed fluorescent yellow-green for leak detection purposes. Enables freeze protection to below -50°C (-60°F) and burst protection to below -73°C (-100°F).
DOWCAL™ N Heat Transfer Fluid
An ethylene glycol-based heat transfer fluid for use in a wide range of industrial, construction, and infrastructure applications. Recommended operating temperature of this fluid ranges from -50°C to 175°C.
Precision Heat Management for Active Pharmaceutical Ingredient Manufacturing
Silicone‑based heat management fluids are used in chemical peptide and small molecule active pharmaceutical ingredient synthesis because they deliver thermal stability and precise temperature control within processing.
Dow provides free annual analysis to qualifying customers.
Benefits
- Excellent thermal stability and reliable low temperature performance (e.g., SYLTHERM™ XLT Heat Transfer Fluid used at –100°C and heated up to +260°C).
- Low acute oral toxicity. In the United States are not listed as reportable under SARA title III, Section 313.
- Process‑enablers support yield, stereochemical integrity, and campaign flexibility.
- Silicone fluids offer superior fluid lifetime and performance vs. glycol-based technologies.
Explore Highlighted Products
SYLTHERM™ 800 Stabilized Heat Transfer Fluid
A specially formulated, highly stable, long-lasting silicone polymer designed for high-temperature liquid phase heat transfer fluid applications, with a recommended operating temperature range of -40°F to 750°F (-40°C to 400°C).
SYLTHERM™ XLT Heat Transfer Fluid
A specially formulated, high-performance silicone polymer designed for use as a low temperature, liquid-phase heat transfer fluid, offering outstanding low temperature heat transfer and pumpability.
SYLTHERM™ HF Heat Transfer Fluid
A specially formulated, high performance silicone polymer designed for use as a low temperature, liquid phase heat transfer fluid, with a recommended use temperature range of -100°F to 500°F (-73°C to 260°C).
Enabling Controlled Environments with Trusted Heat Management Fluids
Pharmaceutical heat management fluids are used in Heating, Ventilation, and Air Conditioning (HVAC) systems as closed‑loop thermal media that enable precise and reliable control of temperature and humidity across cleanrooms and production spaces. Specialty formulated propylene glycol and water mixtures are the industry standard.
Benefits
- No direct contact between HVAC fluid and pharmaceutical processes as glycol loop acts as a secondary refrigerant.
- Support long‑term validated HVAC performance.
- DOWFROST™ Heat Transfer Fluids are NSF HT-1 certified.
Explore Highlighted Products
DOWFROST™ Heat Transfer Fluid
A formulation of 96% food grade propylene glycol plus food grade corrosion inhibitors. Enables freeze protection to below -50°C (-60°F) and burst protection to below -73°C (-100°F). It is made entirely from food grade raw materials conforming to FDA CFR 21 and NSF guidelines.
DOWFROST™ HD Heat Transfer Fluid, Dyed
A formulation of 94.0% propylene glycol and a specially designed package of industrial corrosion inhibitors. The fluid is dyed fluorescent yellow-green for leak detection purposes. Enables freeze protection to below -50°C (-60°F) and burst protection to below -73°C (-100°F).
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