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Liquid Oral Dose
Multipurpose excipients enabling your formulation
Enhance API solubility and stabilize color, flavor, and other ingredients, in liquid oral dose formulations with solutions from Dow.
Your Solutions
Polyethylene Glycol (PEG) & Propylene Glycol (PG)
Polyethylene Glycol (PEG) & Propylene Glycol (PG) function as co-solvents enhancing the solubility of active pharmaceutical ingredients. PEG is a preferred solubilizer for alcohol-free and pediatric formulations.
Edetate Disodium (EDTA)
VERSENE™ NA Chelating Agent (Edetate Disodium USP, Disodium EDTA) is used to stabilize color, and flavors for syrups and elixirs.
Excipients for liquid oral dose application
Finding the right solubilizer - made easy
Class II & Class IV Active Pharmaceutical Ingredients prove challenging for formulators. These compounds usually require advanced formulation techniques to enhance their solubility.
CARBOWAX™ SENTRY™ Polyethylene Glycols (PEG) & Methoxypolyethylene Glycols (MPEG):
- Trusted solubilizers for poorly water-soluble APIs
- Globally accepted - found in prescriptions and over the counter formulations all over the world
- Low aldehyde grades available for concerns of API oxidation
Reduce degradation risks
Active ingredients are vulnerable to oxidation and metal-catalyzed degradation; help protect your formulation stability with Dow excipients.
VERSENE™ NA Edetate Disodium:
- Partially neutralized salt of EDTA in dry form
- Suitable for pharmaceutical formulations
- Extends operational life of in-process liquids
- Stabilizes color, flavor and other ingredients in liquid oral dose
Low Aldehyde Grades
Oxidative degradation of APIs occurs in the presence of elevated peroxide levels leading to a decreased therapeutic effect and poor long-term stability of the finished drug product.
The presence of aldehydes can lead to:
- Formation of acids, i.e. formic acid and acetic acid, decreasing the apparent pH of the drug solution
- Decrease in pH can affect the stability of active pharmaceutical ingredients that are sensitive to hydrolyticdegradation
- Long-term and short-term stability of the final formulation can be affected
CARBOWAX™ SENTRY™ PEGs Low Aldehyde:
- Strict specifications on peroxide and aldehyde levels
- Improved short and long-term stability of APIs in the formulation
- Uniform dissolution and drug release profiles
Recommended products:
Starter formulations for cough & cold*
Swipe to Scroll
| Ingredients | Qty in mg/mL |
|---|---|
| Acetaminophen | 32.5 |
| Guaifenesin | 20 |
| PURAGUARD™ USP/EP Propylene Glycol | 125 |
| CARBOWAX™ SENTRY™ Polyethylene Glycol 600 NF Low Aldehyde, Macrogol 600 Ph. Eur. | 350 |
| Sucrose 60/200 | 250 |
| Sorbitol 70/70 | 125 |
| Sweetener | 5 |
| pH adjuster | 0.7 |
| Antimicrobial | 2 |
| Thickener | 2 |
| Flavoring agent | 2 |
| VERSENE™ NA Chelating Agent | 0.05 |
| Coloring agent | 0.01 |
| Purified water | qs 100 mL |
* Leveraged from Patent # US20080085892A1
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