Enabling more efficient drug processing
There is an industry-wide shift from producing medicine in batches to the continuous processing of medicine like dry powder processing. Dry powder processing is more sustainable because it involves less production steps than wet granulation. It also avoids the degradation of moisture-labile or heat-sensitive active pharmaceutical ingredients (APIs).
METHOCEL™ DC2 excipients offer flowable hypromellose (HPMC) for dry powder processing techniques. They are engineered for improved dry powder flow with expected controlled release performance, facilitating greater tablet weight, excellent protection for heat and moisture sensitive APIs and content uniformity when used in dry powder processing techniques.
METHOCEL™ DC2 helps shorten development time and reduces manufacturing costs by up to 60%, while achieving up to 15% higher press operation speed.
AFFINISOL™ High Productivity HPMCAS
AFFINISOL™ Hypromellose Acetate Succinate (HPMCAS) is a soluble polymer that can help optimize solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization. In addition, AFFINISOL™ HPMCAS offers more polymer tailoring options than peer offerings by enabling flexibility in acetate and succinate substitution levels.
For increased productivity, Dow developed AFFINISOL™ High Productivity HPMCAS, which facilitates higher solids content in solution for higher throughput in spray-drying, while maintaining solubility enhancement from HPMCAS. AFFINISOL™ High Productivity HPMCAS also offers process scale-up efficiencies and greater drug-product utility.
ETHOCEL™ High Productivity
In trials conducted by Dow, use of ETHOCEL™ HP reduced overall coating times by 60% when compared to aqueous or methacrylate systems and by 40% relative to solvent systems. Such faster coating times could enable pharmaceutical companies to increase their productivity yields.
Beyond its productivity attributes, ETHOCEL™ HP also offers significant environmental and sustainability benefits because it is designed to operate solvent free in rotor coater systems. By using the product, formulators can avoid high solvent costs (each kilogram of ETHOCEL HP avoids use of 11.5 kilograms of solvent), eliminate solvent disposal costs (which can be up to 30% of the original solvent cost), improve sustainability, eliminate capital expenditure for solvent-rated equipment and improve operational safety (removing the toxicity concerns associated with solvent use and fume exposure).