Hot Melt Extrusion

The versatile and sustainable plant-based polymer Hypromellose (HPMC) has a long history of safe and effective use as an excipient and controlled-delivery component in oral medications.

However, the application of HPMC into hot melt extrusion (HME) formulations has been successful but limited due to the narrow temperature range between thermal softening and discoloration, the high melt viscosity and the need to use plasticizers to broaden the processing range, which can be detrimental to the final product.

To address this challenge, Dow has designed the cellulosic polymer AFFINISOL™ HPMC HME, which maintains the crystallization inhibiting properties of traditional HPMC, but can be extruded over a wide temperature range without the use of plasticizers.

Other solutions for HME in Dow’s portfolio include ETHOCEL™, polymers which can help formulators to obtain specific release profiles, and POLYOX™ resins that can be used in HME formulations to enhance film-making properties (oral films) and dosage toughness (abuse deterrence).  

Solutions for Hot Melt Extrusion