About two-thirds of all prescription medication is dispensed in solid dosage forms, and half of these are compressed tablets. Patients like them because they can be sure of dose accuracy. They are compact, portable, bland in taste, and easy to take. Manufacturers like tablets because they are simple, economic, stable and convenient to handle.
Yet, while they look simple, tablets are really complex mixtures of crystalline or granular materials that are combined with binders, modified release polymers, solubility enhancement, coating and taste-masking technology. Dow offers a broad portfolio of solutions to balance the technical complexity of the formulation with the required performance.
Solutions for Tablets
METHOCEL™ products offer a micro-thin glossy coating that is printable, hypo-allergenic, non-tacky, and compatible with pigments and dyes. METHOCEL™ polymers can also deliver a consistent drug release performance. In addition, METHOCEL™ VLV Premium tablet coatings are designed to be easily swallowed and minimize overall cycle coating time.
ETHOCEL ™ Polymers
ETHOCEL™ polymers offer versatility in drug release rates and produces hard tablets with low friability. ETHOCEL™ polymers are often used for solvent granulation of water-sensitive materials. The water-insoluble nature of ETHOCEL™ prevents immediate dissolution upon ingestion, which masks the taste of drugs.
POLYOX™ resins provide a viable alternative for use in matrices and osmotic systems due to their high swelling characteristics. The thermoplasticity and gelling behavior of POLYOX™ also makes it a successful candidate in discouraging abuse.
AFFINISOL™ polymers provide process and performance tailoring to address the solubility requirements of your APIs in solid dispersions, whether formulated via Spray-Dried Dispersion or Hot Melt Extrusion.
CARBOWAX™ SENTRY™ PEGs
CARBOWAX™ SENTRY™ PEGs are effective plasticizers in tablet coating formulations, which provide good hardness, water solubility and lubricity.
AMBERLITE™ Ion Exchange Resins
AMBERLITE™ ion exchange resins offer a unique solution to control the release of APIs in tablets, liquid suspensions and semi solids. Ion exchange resins can be used in combination with other excipients to provide targeted drug release profiles.
DUOLITE™ Ion Exchange Resins
DUOLITE™ AP143 resins offer an exceptional solution to control the release of APIs in liquid suspensions and semi solids. The ion exchange resins can be used in combination with other excipients to provide targeted drug release profiles.
ENTERACT™ HPMCAS polymers provide functional coating options for targeted enteric delivery.
WALOCEL™ C Polymers
Low-viscosity WALOCEL™ C grades offer highly transparent solutions which make these grades ideal for tablet coatings.