Controlling or modifying the rate, extent and time of a drug’s delivery can optimize its performance in many ways. However, the development of high-quality tablet and capsule formulations can be a substantial challenge because of a broad array of formulation and process variables that can interact in complex ways.
To address this challenge, Dow designed a broad range of technologies including cellulosics andion exchange technologies. Our strength is our commitment to quality and consistency. Our products are fully certified for use, come in a wide variety of molecular weights and offer innovations for all kinds of tablet designs, including swellable-core technologies.
Solutions for Controlled/Modified Release
METHOCEL™ polymers are designed to deliver a consistent drug release performance. Their varying molecular weights and chemical substitutions are ideal features to modify and control the release of APIs.
ETHOCEL™ polymers offer versatility in drug release rates, producing hard tablets with low friability.
ETHOCEL™ can be used to modify the release profile of an inert matrix without swelling or dissolving. The polymers also offer a versatile diffusion barrier for multiparticulates while forming strong films with good adhesion. ETHOCEL™ films provide durable rate-modifying barriers which can be compressed without fracturing.
AFFINISOL™ HPMC HME Polymers
AFFINISOL™ HPMC HME is designed for use by pharmaceutical companies looking to enhance solubilization and inhibit the recrystallization of APIs in hot melt extrusion (HME) formulations.
Thanks to its lower glass transition temperature (Tg) and a greater processing window, AFFINISOL™ HPMC HME also provides drug formulators with new capabilities to formulate amorphous solid dispersions and controlled release profiles via extrusion processes.
POLYOX™ resins provide a viable alternative for use in matrices and osmotic systems due to its high swelling characteristics. The resins hydrate rapidly to form a gel layer on the tablet surface for the controlled release of APIs. Because POLYOX™ is non-ionic, no interaction between drug and polymers is to be expected.
AMBERLITE™ Ion Exchange Resins
AMBERLITE™ resins offer a unique solution to control the release of APIs in liquid suspensions and semi-solids. The ion exchange resins can be used in combination with other excipients to provide targeted drug release profiles.
DUOLITE™ Ion Exchange Resins
DUOLITE™ resins offer a unique solution to control the release of APIs in liquid suspensions and semi-solids. The ion exchange resins can be used in combination with other excipients to provide targeted drug release profiles.