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  • Propylene Glycol

Propylene glycol (PG) is a clear, colorless liquid with the consistency of syrup. It is practically odorless and tasteless. It is hygroscopic (attracts water), has low toxicity and outstanding stability, as well as high flash and boiling points, low vapor pressure and broad solvency. In addition, propylene glycol is an excellent solvent for many organic compounds and is completely water-soluble. These properties make PG ideal for a wide array of applications, such as:

  • Antifreezes, Coolants and Aircraft Deicing Fluids
  • Chemical Intermediates
  • Cosmetics and Personal Care Products
  • Flavors and Fragrances
  • Food
  • Heat Transfer Fluids
  • Hydraulic Fluids
  • Pharmaceuticals
  • Plasticizers
  • Solvents
  • Thermoset Plastic Formulations

The Chemical Make-up

The structural formulas of the propylene glycols (and their isomers) commercially produced by Dow are:

 

A Closer Look at Quality, From Manufacturing through Delivery

The entire product supply process for DOW PuraGuard™ PG USP/EP is designed and monitored for consistent quality and purity. For over a decade, we have embraced and advocated Responsible Care®, a voluntary, industry-wide commitment to safely handle our chemicals from inception in the laboratory to ultimate disposal. We employ rigorous quality control procedures, including where appropriate, current Good Manufacturing Practices (cGMP) guidelines that govern every aspect of production and shipment of products regulated by the United States Food and Drug Administration (FDA).

Manufacturing
Propylene glycol (PG) is manufactured from propylene oxide, a petroleum-based raw material. As the leading global producer of PG, Dow manufactures approximately 1.2 billion pounds annually.

Dow produces PG products to exacting specifications in modern production facilities with advanced process and analytical instrumentation. Routine use of quality techniques, such as statistical quality control and statistical process control, at all of Dow's PG production plants enables Dow to manufacture PG products that meet or exceed our customers' requirements.

Dow's quality management system conforms to specified requirements of international standards like ISO 9001. In addition, specific grades of Dow monopropylene glycol and dipropylene glycol meet the standards of purity required for food, cosmetic and pharmaceutical applications.

DOW PuraGuard™ Propylene Glycol USP/EP is manufactured in compliance with current Good Manufacturing Practices (cGMP and GMP) requirements and meets GMP guidelines set by the International Pharmaceutical Excipient Council (IPEC).

DPG LO+ is manufactured following Cosmetics Good Manufacturing Practices (CGMP).

Handling
The information given here is for use as a general overview; it may not be complete, and some uses may have been overlooked. Please obtain copies of safety data sheets (SDS) for specific handling and use information about propylene glycols. Visit our Library to read and download SDS for Dow's propylene glycols offering.

With low oral toxicity, PG is generally recognized as safe (GRAS) by the U.S. Food and Drug Administration in 21 CFR § 184.1666, for use as a direct food additive under the conditions prescribed. It is approved by the U.S. FDA for certain indirect food additive uses. PG is used in cosmetics and as an excipient in pharmaceuticals.

Monopropylene glycol (PG), dipropylene glycol (DPG) and tripropylene glycol (TPG) do not normally irritate skin or eyes. Therefore, any irritation should be transient.

MPG, DPG and TPG have low vapor pressures, suggesting that inhalation exposure would not be expected under normal circumstances.

Dow offers its DOW PuraGuard™ Propylene Glycol USP/EP grade of MPG for foods, pharmaceuticals, cosmetics and other applications involving possible ingestion or absorption through the skin, and its Propylene Glycol Industrial Grade (PGI) of MPG for other uses.

Dow offers its Dipropylene Glycol LO+ (DPG LO+) for cosmetics, personal care and other applications involving possible ingestion or absorption through the skin, and Dipropylene Glycol Regular Grade (DPG) for other uses.

Storage
DOW PuraGuard™ Propylene Glycol USP/EP has a shelf life of two years when stored as recommended by Dow.

PGI, DPG and DPG LO+ have a shelf life of one year when stored as recommended by Dow.

TPG and TPG Ac have a shelf life of six months when stored as recommended by Dow.

Distribution
Dow's quality standards are extended to our authorized distributors. Dow reviews and qualifies all distributors to ensure product is handled according to Dow, GMP and Good Distribution Practices guidelines.



To learn more, please go to Products or Contact Us for more specific product and application support. For more information regarding Dow's commitment to GMP and cGMP or for Propylene Glycol's Safety Data Sheets, Tech Data Sheets and other technical documents, please visit Resources or use Literature Locator.

®Responsible Care is a registered service mark of the American Chemistry Council
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DOW PuraGuard™: Your Security for Purity (3:34)


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