We have considerable analytical capabilities to support bioprocess development ranging from high throughput automated analytical methods to detailed protein characterization.  Our team has a breadth of expertise in separation sciences, immunochemical techniques, mass spectrometry, automation, spectroscopy, and protein biochemistry.

SPEED

  • Quantitative expression analysis using high throughput SDS-capillary gel electrophoresis and high throughput biolayer interferometry suitable for analysis of strain expression at the 96 well scale.
  • Quality analysis using HPLC, ELISA, enzyme assays, function-specific assays, automated small-scale protein purification throughout process development.
  • Protein identification by MALDI-TOF and MS/MS amino acid sequencing.

QUALITY

  • Assessment of microheterogeneity using and assortment of HPLC methods, high performance capillary electrophoresis, and mass spectrometry.
  • Low level impurity monitoring by host cell protein ELISA, host DNA quantitative PCR, LAL for endotoxin, LC-MS/MS and GC-MS.
  • Structure and function assessment by fluorescence spectroscopy, multi-angle laser light scattering, quasi-elastic light scattering, and biolayer interferometry.