Year	Event	Reference/Notes
1962	First publication describing preparation and antimicrobial activity of CTAC	The antibacterial activity of a series of quaternaries prepared from hexamethylenetetramine and halo hydrocarbons. Scott, Charles R.; Wolf, Paul A. Dow Chemical Company., Midland, MI, Applied Microbiology (1962), 10 211-16
1965	FDA approval as preservative in adhesives	Food additives. Adhesives. Anon. Federal Register (1965), 30 5509.
1966	Patented for use in aqueous dispersions	Preservation of aqueous dispersions. Wolf, Paul A.; Scott, Charles R. (Dow Chemical Company). (1966), 3 pp. US 3228829
1970	FDA approval (for use in the manuf. of polyurethane resins to be used in contact with dry bulk foods)	Food additives. Polyurethane resins. Anon. Federal Register (1970), 35(140), 11621-2.
1972	Peer-reviewed publication on efficacy in paints	Biological evaluation of preservative agents in emulsion paints. Gambini, R. Dow Chemical Europe S.A., Horgen, Switz. Double-Liaison (1972), 19 :265-73.
1972	EPA registration of Dowicil 75	Registration Number: 464-403. Approval Date: 10-16-72. US EPA
1972	FDA approval (as a preservative in latexes used as pigment binders in paper and paperboard intended for contact with fats and dry solids at room temp. and below.)	Food additives. Components of paper and paperboard in contact with aqueous and fatty foods. Anon. Food Drug Adm., Washington, DC, USA. Federal Register (1972), 37(247), 28285-6.
1977	Peer-reviewed publication on properties as cosmetic preservative	Properties of Dowicil™ 200 preservative. Marouchoc, S. Ross. Des. Prod. Dep., Dow Chem. U.S.A., Midland, MI, USA. Cosmetics & Toiletries (1977), 92:91-3.
1977	FDA approval (in latexes used as pigment binders in paper and paperboard intended for contact with nonacidic nonalcoholic foods.)	Food additives. Components of paper and paperboard in contact with aqueous and fatty foods. Anon. Food Drug Adm., Washington, DC, USA. Federal Register (1977), 42(251), 65150.
1983	Use as a preservative in joint compond patented	Spackeling composition. Deer, Carmine A.; Cacossa, Frank G. (Sand and Sea Corp., USA). U.S. (1983) US 4391647
1997	Stable liquid formulation developed	Stable liquid antimicrobial suspensions of quaternary 3,5,7-triaza-1-azoniaadamantane derivatives. Young, Tracy L.; Brondsema, Philip J. (Dow Chemical Company, USA). PCT Int. Appl. (1997), WO 9730588 A1