Dow Water & Process Solutions

Biotech / Pharma and Fine Chemicals

A wide range of commercial products are produced today using fermentation, synthetic processing, or a combination there-of. These range from products such as animal grade amino acids, antibotics, food and chemical grade organic acids, vitamins, pharmaceuticals, and fine chemicals. In fact for many processes their commercial viability depends on the costs associated with recovery and purification.

DOWEX™ ion exchange and adsorbent resins can be applied to treat process streams at various stages of a production process. Typically, resins can be engaged at various stages of the separation process like, matrix reduction, process purification, and final purification steps.

DOWEX ion exchange resins offer durability under various operating conditions and the highest operating capacity and consistency, resulting in lower operating costs. 

DOWEX Resins for Fermentation and Biotech

Product	Description	Type	Matrix	Total Exchange Capacity* eq/l (kgr/ft3)	Available Forms
DOWEX 1X2	Fine mesh resin for fine chemical and pharmaceutical column separations.	Fine Mesh	Styrene-DVB, Gel	0.6 meq/mL	Cl-
DOWEX 1X4	Fine mesh resin for fine chemical and pharmaceutical column separations.	Fine Mesh	Styrene-DVB, Gel	1.0 meq/ml	Cl-
DOWEX 1X8	Fine mesh resin for fine chemical and pharmaceutical column separations.	Fine Mesh	Styrene-DVB, Gel	1.2 meq/ml	Cl-
DOWEX 50WX2	Fine mesh resin for fine chemical and pharmaceutical separations.	Fine Mesh	Styrene-DVB, Gel	0.6 meq/ml	H+
DOWEX 50WX4	Fine mesh resin for fine chemical and pharmaceutical column separations.	Fine Mesh	Styrene-DVB, Gel	1.1 meq/ml	H+
DOWEX 50WX8	Fine mesh resin for fine chemical and pharmaceutical column separation.	Fine Mesh	Styrene-DVB, Gel	1.7 meq/ml	H+
DOWEX Retardion 11A8 50 - 100 mesh	Amphoteric resin containing both weak acid cation and strong base anion functionality within the same resin.	Amphoteric resin	Styrene-DVB, Gel	1.1 meq/mL (24.1 kgr/ft3) 1.2 meq/ml (26.3 (kgr/ft3)	-COOH and -N(CH3)3
DOWEX OPTIPORE SD-2	Polymeric adsorbent used to decolorize HFCS, corn syrup, sucrose and fruit juices. Meets CFR 173.25.	Adsorbent	Styrene-DVB, Macroporous		Hydrophic
DOWEX 66	Ion exchange resin for sweetener applications.	Weak Base Anion	Styrene-DVB, Macroporous	1.6	FB (Free Base)
DOWEX MARATHON A	A uniform particle size, high capacity, strong base anion exchange resin for demineralization applications.	Type I Strong Base Anion	Styrene-DVB, Gel	1.3 (28.4) 1.0 (21.9)	Cl- and OH-
DOWEX 22	Ion exchange resin for sweetener applications, specifically designed for good kinetics and high performance in critical, mixed bed polishing of sugars.	Type II Strong Base Anion	Styrene-DVB, Macroporous	1.2 (24.0)	Cl-
DOWEX 88	Ion exchange resin for sweetener applications.	Strong Acid Cation	Styrene-DVB, Macroporous	1.8	Na+
DOWEX MARATHON C	A uniform particle size, high capacity cation exchange resin for industrial and residential softening and demineralization applications.	Strong Acid Cation	Styrene-DVB, Gel	2.0 (43.7) 1.8 (39.3)	Na+ and H+
DOWEX N406	A uniform particle size strong acid cation exchange resin for fermentation and fine chemical applications	Strong Acid Cation	Styrene-DVB, Gel	2.0 (43.7)	H+
DOWEX MAC-3	A macroporous weak acid cation exchange resin used for water softening, dealkalization, and demineralization applications.	Weak Acid Cation	Polyacrylic, Macroporous	3.8 (83.0)	H+
DOWEX MARATHON MR-3	Uniform particle size, high capacity, mixed ion exchange resin for demineralization.	1 : 1 by equivalent cation : anion	Styrene-DVB, Gel	1.0 (21.9) 1.8 (39.3)	OH- and H+

Suggested Reading: F. J. Dechow, "Separation and Purification Techniques in Biotechnology," Noyes Publicaiton, 1989 D. J. Gisch, "Genetic Engineering News" 2001, Volume 21, February, page 48-51.