Pharmaceutical Processing

DOWTHERM™, DOWFROST™ and SYLTHERM†1 Heat Transfer Fluids are used for batch processing of pharmaceutical products in multi-purpose reactors. Heat transfer fluids with broad operating temperature ranges are required so that chemical reactions can take place at high temperatures and crystallization of the final products can occur at very low temperatures. Several Dow fluids are favored by the pharmaceutical industry.

SYLTHERM XLT Silicone Fluid is one of the leading product used in pharmaceutical batch processing. The fluid operates from -100ºC (-150°F) up to 260°C (500°F), has essentially no odor, is very low in acute oral toxicity, and is not listed as reportable in the U.S. under SARA Title III, Section 313.

DOWTHERM J Synthetic Organic Fluid offers high temperature performance. The fluid can be used in liquid phase as low as -80°C (-110°F) and up to 315°C (600°F). It is the fluid of choice for the most demanding single fluid heating and cooling applications.

Other Dow fluids are also useful for pharmaceutical batch processing. DOWTHERM 4000 and DOWCAL 100 Inhibited Ethylene Glycol-based Fluids offer low temperature pumpability down to -28.9°C (-20°F) and high temperature operation up to 175°C (350°F); DOWFROST HD and DOWCAL 20 Inhibited Propylene Glycol-based Fluids offer the advantage of lower toxicity with recommended operating ranges from -45°C (-50°F) to 160°C (325°F).

For applications where regulatory compliance is a concern, DOWCAL N and DOWFROST Inhibited Propylene Glycol-based Fluids have recommended operating ranges of -45°C (-50°F) to 120°C (250°F). The ingredients in DOWFROST and DOWCAL N Fluids are considered safe by the U.S. FDA food additive regulations for use in applications where incidental contact with food, potable water or other products for human consumption is possible.

Product Geographic Availability Product Description
SYLTHERM XLT HTF PDF North America
Latin America
Europe
Asia-Pacific, India, Middle East & Africa
-100°C to 260°C
(-150°F to 500°F)
SYLTHERM 800 Stabilized HTF North America
Latin America
Europe
Asia-Pacific, India, Middle East & Africa
-40°C to 400°C
(-40°F to 750°F)
SYLTHERM HF HTF North America
Latin America
Europe
Asia-Pacific, India, Middle East & Africa
-73°C to 260°C
(-100°F to 500°F)
DOWTHERM J North America
Latin America
Europe
Asia-Pacific
-80°C to 315°C (-100°F to 600°F)
Vapor Phase: 181°C to 315°C (358°F to 600°F)
DOWCAL 100 PDF Europe
India
Middle East
Africa

HVAC
Pharmaceutical
Secondary cooling and heating
Freeze, burst protection
Renewable energy

-50°C to 170°C
(-60°F to 350°C)
DOWCAL 200 PDF Europe
Middle East
Africa
-50°C to 175°C
(-60°F to 350°F)
DOWCAL N PDF Europe
Middle East
Africa
-45°C to 120°C
(-60°F to 250°F)
DOWTHERM SR-1 PDF
(Various concentrations available)
North America
Latin America
Asia-Pacific, India, Middle East & Africa
-50°C to 120°C
(-60°F to 350°F)
DOWTHERM 4000 PDF North America
Latin America
Asia-Pacific, India, Middle East & Africa
-50°C to 175°C
(-60°F to 350°F)
DOWTHERM 4000 55% Solution PDF North America
Latin America
Asia-Pacific, India, Middle East & Africa
-50°C to 175°C
(-60°F to 350°F)
DOWFROST PDF
(Various concentrations available)
North America
Latin America
Asia-Pacific, India, Middle East & Africa
-45°C to 120°C
(-50°F to 250°F)
DOWFROST HD
(Various concentrations available)
North America
Latin America
Asia-Pacific, India, Middle East & Africa
-45°C to 160°C
(-50°F to 325°F)


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