Cultivating a Passion for Discovery

Dr. William (“Jack”) J. Kruper, Jr.

Dow Corporate Fellow,
Chemical Sciences, Core R&D
human-element

Tackling Nuclear Physics in Second Grade

As a scientist and a gardener, Jack Kruper is all about digging deep.

Jack Kruper’s interest in science started early in life. In the second grade, while other boys his age were reading comic books, Jack was reading up on nuclear processes and unstable isotopes. “I was very interested in physics at that time,” he said. But he didn’t actually discover his life’s passion until he went to the University of Michigan in Dearborn.

“When I started college, I didn’t really know what I wanted to do in science, even after taking general chemistry. But when I took my first organic chemistry class, I knew that was it,” he said. “I was fascinated by the idea of being able to make anything in nature – or discover new molecules. I was fortunate to have two great professors who were outstanding mentors and helped cultivate my interest in chemistry.”

Jack’s interest in organic chemistry led to more than 33 years as a research chemist with Dow, earning multiple awards of distinction, conducting seven years of promising cancer research and authoring 23 peer-reviewed articles. He holds more than 70 U.S. patents, as well as over 750 internationally granted/applied patents. Jack is a recognized expert in renewable feedstock utilization, olefin polymerization, non-sedating antihistamines, anti-cancer radiopharmaceuticals, and carbon dioxide activation. (He also met his wife while working for Dow – Cynthia Rand, who was also a research fellow at Dow, now retired.)

With all of his commercial accomplishments, Jack has never lost his fascination for discovery and lab work. “Even after all these years working on many different commercial projects, I still enjoy working in the lab. Wrestling with a molecular concept, or figuring out how to enable a new process – it never gets old for me,” Jack said.

Cultivating the Next Generation of Scientists

Just like the professors who mentored him in college, Jack is now well-known for cultivating a passion for discovery with the next generation of scientists. For many years, he led “Friday Afternoon Experiments” – inspiring other researchers at Dow to join him in the lab on Fridays to try out new ideas. More than a few of those Friday experiments eventually turned into commercial projects.

He also championed Dow’s University Funded Initiative at Northwestern University and the University of Wisconsin to enhance relationships with professors and graduate students, while providing funding for research of promising new technologies.

“My advice to young scientists today is first to realize that success in any field starts with technical prowess and a passion for discovery,” Jack said. “I tell them you won’t have a eureka in the lab every day. There’s a lot of hard, sweaty work that must be done in the lab to be a successful researcher.

“At the same time, to grow and move forward in your career, I let young scientists know that they can’t do it alone. It’s essential to be able to put together a team of people from many different disciplines, articulate your goal, and get others excited about accomplishing that goal. Research projects are so complicated today, scientists need to dig deep and cultivate many different relationships to be successful and create value.”

Awards

ACS Award in Affordable Green Chemistry

ACS Award in Chemistry Mentorship

Six Dow Inventor of the Year Awards

Dow Excellence in Science Award

Associations

ACS

Dow’s University Funded Initiative at Northwestern University and the University of Wisconsin

Chair-Elect for 2016 Green Chemistry Gordon Conference

US8,586,522: “Glycol dilevulinates as coupling agents in cleaning formulations”

US8,581,012: “Processes for the production of chlorinated and/or fluorinated propenes and higher alkenes”

US8,581,011: “Process for the production of chlorinated and/or fluorinated propenes”

US8,574,773: “Battery electrolyte solutions containing aromatic phosphorus compounds”

US8,558,041: “Isothermal multitube reactors and processes incorporating the same”

US8,450,383: “Extruded polymer foams containing esters of a sugar and a brominated fatty acid as a flame retardant additive”

US8,404,905: “Batch, semi-continuous or continuous hydrochlorination of glycerin with reduced volatile chlorinated hydrocarbon by-products and chloroacetone levels”

US8,324,288: “Extruded polymer foams containing brominated fatty acid-based flame retardant additives”

US8,304,563: “Batch, semi-continuous or continuous hydrochlorination of glycerin with reduced volatile chlorinated hydrocarbon by-products and chloroacetone levels”

US8,258,353: “Process for the production of chlorinated and/or fluorinated propenes”

US8,236,975: “Process for the conversion of a crude glycerol, crude mixtures of naturally derived multicomponent aliphatic hydrocarbons or esters thereof to a chlorohydrin”

US8,114,943: “Process for brominating butadiene/vinyl aromatic copolymers”

US8,088,957: “Conversion of a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin”

US8,080,592: “Extruded polymer foams containing brominated fatty acid-based flame retardant additives”

US8,058,332: “Phosphorus-sulfur FR additives and polymer systems containing same”

US7,910,781: “Process for the conversion of a crude glycerol, crude mixtures of naturally derived multihydroxylated aliphatic hydrocarbons or esters thereof to a chlorohydrin”

US7,906,690: “Batch, semi-continuous or continuous hydrochlorination of glycerin with reduced volatile chlorinated hydrocarbon by-products and chloracetone levels”

US6,825,295: “Alkaryl-substituted group 4 metal complexes, catalysts and olefin polymerization process”

US6,777,555: “Intermediates useful for the preparation of antihistaminic piperidine derivatives”

US6,683,199: “Dicationic non-metallocene group 4 metal complexes”

US6,673,735: “Preparation of catalyst compositions”

US6,566,526: “Intermediates useful for the preparation of antihistaminic piperidine derivatives”

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US6,555,634: “Di- and tri-heteroatom substituted indenyl metal complexes”

US6,552,200: “Intermediates useful for the preparation of antihistaminic piperidine derivatives”

US6,548,675: “Intermediates useful for the preparation of antihistaminic piperidine derivatives”

US6,528,449: “Three coordinate aluminum catalyst activator composition”

US6,515,155: “Substituted group 4 metal complexes, catalysts and olefin polymerization process”

US6,479,663: “Intermediates useful for the preparation of antihistaminic piperidine derivatives”

US6,441,179: “Intermediates useful for the preparation of antihistaminic piperidine derivatives”

US6,420,299: “Boron-substituted cyclopentadienes and metal complexes thereof”

US6,387,838: “Activator composition comprising aluminum compound mixture”

US6,367,387: “Low-calibre shot gun bullet, especially for shot guns with a partially or fully distended barrel”

US6,348,597: “Intermediates useful for the preparation of antihistaminic piperidine derivatives”

US6,340,761: “Intermediates useful for the preparation of antihistaminic piperidine derivatives”

US6,312,679: “Dense star polymer conjugates as dyes”

US6,291,614: “Dinuclear fluoroaryl aluminum alkyl complexes”

US6,268,444: “3-heteroatom substituted cyclopentadienyl-containing metal complexes and olefin polymerization process”

US6,242,606: “Intermediates useful for the preparation of antihistaminic piperidine derivatives”

US6,214,760: “Catalyst activator composition”

US6,211,111: “Activator composition comprising aluminum compound mixture”

US6,187,940: “Three coordinate aluminum catalyst activator composition”

US6,177,414: “Starburst conjugates”

US6,160,146: “Process for preparing trifluoroarylaluminum etherates”

US6,147,216: “Intermediates useful for the preparation of antihistaminic piperidine derivatives”

US6,140,521: “Ansa group 4 metal bis (.mu.-substituted) aluminum complexes”

US6,086,864: “Pharmaceutical formulations comprising polythiourea and methods of use thereof”

US5,756,065: “Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents”

US5,739,323: “Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies”

US5,714,166: “Bioactive and/or targeted dendrimer conjugates”

US5,652,361: “Macrocyclic ligands and complexes”

US5,541,349: “Metal complexes containing partially delocalized II-bound groups and addition polymerization catalysts therefrom”

US5,527,524: “Dense star polymer conjugates”

US5,495,036: “Metal (III) complexes containing conjugated, non-aromatic anionic II-bound groups and addition polymerization catalysts therefrom”

US5,489,425: “Functionalized polyamine chelants”

US5,435,990: “Macrocyclic conjugates and their use as diagnostic and therapeutic agents”

US5,371,303: “One-step preparation of 4,6-dinitroresorcinol from resorcinol”

US5,338,532: “Starburst conjugates”

US5,310,535: “Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies”

US5,284,644: “Functionalized polyamine chelants and rhodium complexes thereof for conjugation to antibodies”

US5,106,407: “Iodones and methods for antimicrobial use”

US5,064,956: “Process for preparing mono-n-alkylated polyazamacrocycles”

US4,994,560: “Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies”

US4,746,735: “Regiospecific aryl nitration of meso-substituted tetraarylporphyrins”

US4,727,181: “Process for the preparation of .alpha.-halocinnamate esters”

US4,668,832: “Dehydration of halogenated, unsaturated alcohols to form halogenated, conjugated dienes”

US4,668,710: “Trihalovinyl polyol ethers”

US4,663,467: “Novel porphyrinate and amine composition useful as catalysts in the preparation of alkylene carbonates”

US4,500,704: “Carbon dioxide oxirane copolymer prepared using double metal cyanide complexes”

Beach, Mark; Shankar, Ravi; Kiefer, Joe; Gerhart, Bruce; Froese, Robert; Kruper, Jack; Hu, Terry; Hudack, Michelle; Stobby, Bill; Morgan, Ted; Green, John; Korobeinichev, Oleg; Shmakov, Andrey; Shvartsberg, Vladimir, “Fundamental Studies of the Mechanistic Action of Phosphorus and Sulfur as Key Elements for Flame Retardant Activity in Polystyrene-Flame Retardant Blends,” Proceedings of the Annual Conference on Recent Advances in Flame Retardancy of Polymeric Materials, 2009, 20th, 78-84.

Klosin, Jerzy; Kruper, William J.; Patton, Jasson T.; Abboud, Khalil A., “Synthesis and X-ray Structure of Novel 2- and 3-Heteroatom-Substituted Ansa-Zirconocene Complexes,” Journal of Organometallic Chemistry, 2009, 694(16), 2581-2596.

Bell, Bruce M.; Briggs, John R.; Campbell, Robert M.; Chambers, Susanne M.; Gaarenstroom, Phil D.; Hippler, Jeffrey G.; Hook, Bruce D.; Kearns, Kenneth; Kenney, John M.; Kruper, William J.; Schreck, D. James; Theriault, Curt N.; Wolfe, Charles P., “Glycerin as a Renewable Feedstock for Epichlorohydrin Production: The GTE process,” Clean: Soil, Air, Water, 2008, 36(8), 657-661.

Klosin, Jerzy; Kruper, William J., Jr.; Nickias, Peter N.; Roof, Gordon R.; De Waele, Phillip; Abboud, Khalil A., “Heteroatom-Substituted Constrained-Geometry Complexes. Dramatic Substituent Effect on Catalyst Efficiency and Polymer Molecular Weight,” Catalysis Laboratory, The Dow Chemical Company, Midland, MI, USA, Organometallics, 2001, 20(13), 2663-2665.

Chum, P. Stephen; Kruper, William J.; Guest, Martin J., “Materials Properties Derived from INSITE Metallocene Catalysts,” The Dow Chemical Company, Freeport, TX, USA, Adv. Mater. (Weinheim, Ger.), 2000, 12(23), 1759-1767.

Chen, Eugene Y.-X.; Kruper, William J.; Roof, Gordon; Wilson, David R., “Double Activation of Constrained Geometry and ansa-Metallocene Group 4 Metal Dialkyls: Synthesis, Structure, and Olefin Polymerization. Study of Mono- and Dicationic Aluminate Complexes,” Corporate R&D, The Dow Chemical Company, Midland, MI, USA, J. Am. Chem. Soc., 2001, 123(4), 745-746.

Feng, Shaoguang; Klosin, Jerzy; Kruper, William J. ,Jr.; McAdon, Mark H.; Neithamer, David R.; Nickias, Peter N.; Patton, Jasson T.; Wilson, David R.; Abboud, Khalil A.; Stern, Charlotte L., “Synthesis and Characterization of Cyclohexadienyl-Based Constrained Geometry Complexes,” Catalysis Laboratory, The Dow Chemical Company, Midland, MI, USA, Organometallics, 1999, 18(7), 1159-1167.

Kruper, William J.; Dellar, David D., “Catalytic Formation of Cyclic Carbonates from Epoxides and CO2 with Chromium Metalloporphyrinates,” The Dow Chemical Company, Midland, MI, USA, J. Org. Chem., 1995, 60(3), 725-7.

Kruper, William J., Jr.; Rudolf, Philip R.; Langhoff, Charles A., “Unexpected Selectivity in The Alkylation of Polyazamacrocycle,” The Dow Chemical Company, Midland, MI, USA, J. Org. Chem., 1993, 58(15), 3869-76.

Kruper, William J., Jr.; Emmons, Albert H., “Synthesis of -Halocinnamate Esters via Solvolytic Rearrangement of Trichloroallyl Alcohols,” Org. Chem. Polym. Lab., The Dow Chemical Company, Midland, MI, USA, J. Org. Chem., 1991, 56(10), 3323-9.

Kruper, William J., Jr.; Chamberlin, Thomas A.; Kochanny, Monica, “Regiospecific Aryl Nitration of meso-Substituted Tetraarylporphyrins: A Simple Route to Bifunctional Porphyrins,” Org. Chem. Polym. Lab., The Dow Chemical Company, Midland, MI, USA, J. Org. Chem., 1989, 54(11), 2753-6.

Groves, John T.; Kruper, William J. Jr., “Metalloporphyrins in Oxidative Catalysis. Oxygen Transfer Reactions of Oxochromium Porphyrins,” Dep. Chem., Univ. Michigan, Ann Arbor, MI, USA, Isr. J. Chem., 1985, 25(2), 148-54.

Kruper, William John, Jr., “The Isolation, Characterization and Reactivity of High Valent Oxometalloporphyrinates of Chromium and Manganese,” Univ. Michigan, Ann Arbor, MI, USA, Avail. Univ. Microfilms Int., Order No. DA8314219. 1982, 371 pp. From: Diss. Abstr. Int. B 1983, 44(2), 497.

Groves, John T.; Kruper, William J., Jr.; Haushalter, Robert C.; Butler, William M. Dep. Chem., Univ. Michigan, Ann Arbor, MI, USA, “Synthesis, Characterization, and Molecular Structure of Oxo(porphyrinato)chromium(IV) Complexes,” Inorg. Chem., 1982, 21(4), 1363-8.

Groves, John T.; Kruper, William J.; Nemo, Thomas E.; Myers, Richard S., “Hydroxylation and Epoxidation Reactions Catalyzed by Synthetic Metalloporphyrinates. Models Related to The Active Oxygen Species of Cytochrome P-450,” Dep. Chem., Univ. Michigan, Ann Arbor, MI, USA, J. Mol. Catal., 1980, 7(2), 169-77.

Groves, John T.; Kruper, William J., Jr.; Haushalter, Robert C., “Hydrocarbon Oxidations with Oxometalloporphinates, Isolation and Reactions of a (Porphinato)manganese(V) Complex,” Dep. Chem., Univ. Michigan, Ann Arbor, MI, USA., J. Am. Chem. Soc., 1980, 102(20), 6375-7.

Groves, John T.; Kruper, William J., Jr., “Preparation and Characterization of an Oxoporphinatochromium(V) Complex,” Dep. Chem., Univ. Michigan, Ann Arbor, MI, USA, J. Am. Chem. Soc., 1979, 101(25), 7613-15.

Schott M. E.; Schlom J.; Siler K.; Milenic D. E.; Eggensperger D.; Colcher D.; Cheng R.; Kruper W. J. Jr.; Fordyce W.; Goeckeler W., Biodistribution and Preclinical Radioimmunotherapy Studies Using Radiolanthanide-labeled Immunoconjugates,” Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, CANCER, 1994, 73(3 Suppl), 993-8.

Stern, Jeffrey J.; Cudillo, Cynthia A.; Kruper, Jack., “Ventromedial Hypothalamus and Short-term Feeding Suppression by Caerulein in Male Rats,” J. Comp. Physiol. Psychol., 1976, 90(5), 484-90.

Goeckeler, W.; Cheng, R. A.; Fordyce, W. A.; Kruper, W. J.; Kaplan, D. A., “Comparative Biodistribution of CC-49 Labeled Monoclonal Antibody with Samarium, Yttrium and Lutetitium in Tumored Mice Bearing the LS-174T Human Cancer Xenograft,” J. Nucl. Med. in press.

William J. Kruper*, John W. Hull Jr., Zenon Lysenko, George J. Frycek, Peter Margl* and James R. DeWald, “Metal-Free, Direct Nitration of Resorcinol: A Convenient and Mechanistically Reasonable Route to 4,6-Diaminoresorcinol,” Manuscript in Preparation to J. Org. Chem., 2012.