Cultivating Food, Growing Talent

Beth Lorsbach, Ph.D., Process Chemistry Leader, Dow AgroSciences

Growing the Next Generation of Leaders

By 2050, world food production must support an estimated 9 billion people — all while using the same amount of land and conserving water. This imminent global challenge is top of mind every day for Beth Lorsbach, Ph.D., process chemistry leader for Dow AgroSciences.

Lorsbach, an expert in synthetic organic chemistry, says that creating novel solutions to real-world agriculture challenges is a stimulating job that never gets old. Throughout her career, she’s helped advance new compounds that help with crop protection, with a focus on fungicides.

In particular, she and her team have made great strides recently in the quest for new fungicides to control Septoria tritici, a devastating wheat pathogen that’s of great concern to the cereal market. Lorsbach has helped to advance a novel area of chemistry, aminopyrimidines, which is highly active against this commercially important disease.

“But what I’m most passionate about is certainly the people,” says Lorsbach, who takes her job as a mentor just as seriously as her job as a scientist. “We deal with really tough problems that not anyone can solve. You need to have a collaborative environment so you can bounce ideas off of each other—that’s the secret sauce. With the right people, the sky is really the limit.”

Lorsbach is among 10 scientists nationally to be recognized in 2015 by the American Chemical Society with a Women Chemists Committee (WCC) Rising Star Award. The award recognizes outstanding women scientists approaching mid-level careers who have demonstrated outstanding contributions to their respective fields.
(Read more about the recognition.)

“At the end of the day, you have to love what you do,” says Lorsbach, who received a bachelor’s degree in chemistry from Boston University and a Ph.D. in organic chemistry from the University of California, Davis. “You must be passionate about it.”

Luckily for Dow AgroSciences—which add hundreds of talented scientists to its ranks every year—Lorsbach’s passion for her work is contagious.

Awards

2015 Women Chemists Committee (WCC), American Society Rising Star Award

2009 Indy’s Best and Brightest, finalist (KPMG LLP)

2008 Increase the Slope Award, finalist (Dow AgroSciences)

2003 Discovery Recognition Award for Innovation and Creativity, (Dow AgroSciences)

2002 Leadership Exemplified through Scientific Excellence, (Dow AgroSciences)

1998 Chemistry Merit Award (University of California, Davis)

1997 Chemistry Teaching Award (University of California, Davis)

1995 Brandford Borge Fellowship (University of California, Davis)

1993 Undergraduate Research Award (Boston University)

1993 Student Affiliates Research Award (Boston University)

1991 Boston University Merit Scholarship (Boston University)

Associations

2013 - present Editorial Advisory Board of the ACS journal Organic Process Research & Development (OPRD)

2006 - 2008 Indiana Local American Chemical Society (ACS), Chair

1993 - present American Chemical Society member

Boebel, Timothy A.; Lorsbach, Beth; Martin, Timothy P.; Owen, W.; Sullenberger, Michael T.; Webster, Jeffery; Yao, Chenglin. 2-Aldoximino-5-Fluoropyrimidine Derivatives. (December 16, 2014), US 8,912,207 B2.

Boebel, Timothy A.; Bryan, Kristy; Johnson, Peter L.; Lorsbach, Beth; Martin, Timothy P.; Meyer, Kevin G.; Owen, W.; Sullenberger, Michael T.; Webster, Jeffery; Yao, Chenglin. 5-Fluoropyrimidinone Derivatives. (December 23, 2014), US 8,916,579 B2.

Bryan, Kristy; Davis, George E.; Graupner, Paul R.; Lorsbach, Beth; Owen, W. John;Tisdell, Francis E. Pyrazinyl Carboxamides as Fungicides. (October 14, 2014), US 8,859,558 B2.

Lorsbach, Beth; Owen, W. John; Yao, Chenglin Synergistic Fungicidal Interactions of 5-Fluorocytosine and other Fungicides. (April 29, 2014) US 8,709,458 B2.

Boebel, Timothy A.; Lorsbach, Beth; Martin, Timothy P.; Owen, W. John; Sullenberger, Michael T.; Webster, Jeffery D.; Yao, Chenglin. 5-Fluoro-4-imino-3,4-dihyropyrimidin-2-(1H)-ones Derivatives. (February 25, 2014), US 8,658,660 B2.

Boebel, Timothy A.; Bryan, Kristy; Lorsbach, Beth; Martin, Timothy P.; Owen, W.; Pobanz, Mark; Thornburgh, Scott; Webster, Jeffery; Yao, Chenglin. N1-Substituted-5-Fluoro-2-oxopyrimidinone-1(2H)-Carboxamide Derivatives. (October 8, 2013) US 8,552,020 B2.

Boebel, Timothy A.; Bryan, Kristy; Lorsbach, Beth; Martin, Timothy P.; Owen, W.; Pobanz, Mark; Thornburgh, Scott; Webster, Jeffery; Yao, Chenglin. N1-Acyl-5-Fluoropyrimidinone Derivatives. (June 25, 2013), US 8,470,839 B2.

Klittich, Carla J. R.; Lorsbach, Beth; Meitl, Alice; Owen, W. John; Yao, Chenglin. Synergistic fungicidal compositions containing a 5-fluoropyrimidine derivative for fungal control in cereals. (June 25, 2013), US 8,470,840 B2.

Lorsbach, Beth Anne; Ruiz, James Melvin; Sparks, Thomas Clarence; Sullenberger, Michael Thomas; Morrison, Irene Mae; Webster, Jeffery Dale. N-substituted piperazines. U.S. Pat. Appl. Publ. (December 25, 2012), US 6,338,430 B2.

Boebel, Timothy A.; Bryan, Kristy; Lorsbach, Beth; Martin, Timothy P.; Owen, W.; Pobanz, Mark; Thornburgh, Scott; Webster, Jeffery; Yao, Chenglin. 5-Fluoro-2-oxopyrimidine-1(2H)-Carboxylate Derivatives. (November 27, 2012), US 8,318,758 B2.

Boebel, Timothy A.; Lorsbach, Beth; Martin, Timothy P.; Owen, W.; Sullenberger, Michael; Webster, Jeffery; Yao, Chenglin. N3-Substituted-N1-Sulfonyl-5-Fluoropyrimidinone Derivatives. (September 11, 2012) US 8,263,603 B2.

Lorsbach, Beth Anne; Ruiz, James Melvin; Sparks, Thomas Clarence; Sullenberger, Michael Thomas; Morrison, Irene Mae; Webster, Jeffery Dale. N-substituted piperazines. U.S. Pat. Appl. Publ. (July 13, 2010), US 7,754,724 B2.

Guggenheim, Kathryn G.; Butler, Jeffrey D.; Painter, Phillip P.; Lorsbach, Beth A.; Tantillo, Dean J.; Kurth, Mark J. “Synthesis of Spiro-Fused Pyrazolidoylisoxazolines” Journal of Organic Chemistry 2011 76, 5803-5812

Meng, Liping; Lorsbach, Beth A.; Sparks, Thomas C.; Fettinger, James C.; Kurth, Mark J. “Parallel Synthesis of Bis-heterocyclic Isoxazolylmethyl- and Isoxazolinylmethylpyrazoles” Journal of Combinatorial Chemistry 2010, 12, 129-136.

Milinkevich, Kristin A.; Yoo, Choong L.; Sparks, Thomas C.; Lorsbach, Beth A.; Kurth, Mark J. “Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles.” Bioorganic & Medicinal Chemistry Letters 2009, 19, 5796-5798

Yu, Gui J.; Iwamoto, Satori; Robins, Lori I.; Fettinger, James C.; Sparks, Thomas C.; Lorsbach, Beth A.; Kurth, Mark J. 3-(Arylthiomethyl)isoxazole-4,5-dicarboxamides: Chemoselective Nucleophilic Chemistry and Insecticidal Activity. Journal of Agricultural and Food Chemistry 2009, 57(16), 7422-7426.

Choung, Wonken; Lorsbach, Beth A.; Sparks, Thomas C.; Ruiz, James M.; Kurth, Mark J. 4-(Isoxazol-3-yl)pyrimidines from pyrimidinyl nitrile oxides.” Synlett 2008, 19, 3036-3040

James M. Ruiz and Beth A. Lorsbach. “Computer Aided Library Design for Agrochemical Lead Generation: Design and Synthesis of Ring-Fused 2-Pyridinone Esters”,New Discoveries in AgroChemicals; J.M. Clark, H. Ohkawa, Eds.;. ACS Symposium Series 892; American Chemical Society: Washington, D.C., 2005; p 99.

Benko, Zoltan L.; Davis, George E.; Young, David H.; Owen, John W.; Lorsbach, Beth A. Combinatorial approach to lead generation and the discovery of a novel agent for Septoria tritici control. 248th ACS National Meeting & Exposition, San Francisco, CA, United States, August 10-14, 2014 (2014), AGRO-624.

Lawler, Lori K.; Hegde, Vidyadhar B.; Lorsbach, Beth A.; Loso, Michael R.; Pobanz, Mark A. Partnering for success with contract research organizations (CROs) to enhance discovery R&D productivity. 246th ACS National Meeting & Exposition, Indianapolis, IN, United States, September 8-12, 2013 (2013), AGRO-272.

Lorsbach, Beth A.; Hegde, Vidyadhar; Hunter, James E.; Lambert, William T.; Lawler, Lori K.; Pernich, Daniel J.; Young, David D.; Wang, Nick . Accelerating discovery through risk-sharing collaborations. 246th ACS National Meeting & Exposition, Indianapolis, IN, United States, September 8-12, 2013(2013),AGRO-270.

Brewster, William K.; Camper, Debby; Gundla, Rambabu; Gustafson, Gary D.; Hunter, James E.; Joshi, Hemant; Lo, William J.; Lorsbach, Beth A.; Loso, Michael; Mandaleswaran, Adiraj; Sanam, Ramadev; Arumugan, Premkumar; Pernich, Daniel J. Research directed towards the discovery of novel thymidylate synthase inhibitors as agricultural fungicides. 246th ACS National Meeting & Exposition, Indianapolis, IN, United States, September 8-12, 2013(2013),AGRO-214.

Webster, Jeffery D.; Lorsbach, Beth A.; Olson, Monica; Geng, Chaoxian. Discovery and the structure activity relationship of a series of novel oxadiazole-based insecticides. 246th ACS National Meeting & Exposition, Indianapolis, IN, United States, September 8-12, 2013(2013),AGRO-205.

Benko, Zoltan; Lawler, Lori K.; Lorsbach, Beth; Parker, Marshall; Ruiz, James; Webster, Jeff. Use of Combinatiorial Chemistry to Support Lead Generation Approaches. Abstracts, 42nd Central Regional Meeting of the American Chemical Society, Indianapolis, IN, United States, June 8-10 (2011)

Lorsbach, Beth A.; Ruiz, James M.; Sparks, Thomas C.; Webster, Jeffery D.; Sullenberger, Michael T.; Morrison, Irene. Pharmacophore design and parallel synthesis of phenylpiperidine/phenylpiperazine libraries as insect calcium channel inhibitors. Abstracts of Papers, 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008 (2008),

Sparks, T.C., Lorsbach, B.A., Ruiz, J.M., Webster, J.D., Sullenberger, M.T., Daeuble, J.F., Oliver, M.P. 2008a. Cheminformatics and Lead Generation for Insect Control. 4th Pan-Pacific Conference on Pesticide Science, June 1-5, 2008, Honolulu, HI. Poster presentation, #64.

B. A. Lorsbach; J. D. Webster, J. M. Ruiz, M. L. Foster, P. R. Schmitzer, D. L. Camper “Overview of an Anthranilate Synthase Screening Strategy, Hit Prioritization, and Exploitation of Hits via a Solution-Phase Arylsulfonamide Library” Pan Pacific Conference, Honolulu, Hawaii, December 2005

B. A. Lorsbach, J. M. Ruiz, P. R. Schmitzer “Synthesis and Herbicidal Activity of Substituted 5,6-Fused Ring Heterocycles and Thiazoles.” American Chemical Society Central Regional Meeting, Indianapolis, IN 46220, June 4, 2004.