One of the Best Swelling Polymer Available in the Market
POLYOX™ resins are a family of non-ionic, high molecular weight, water-soluble poly (ethylene oxide) resins. They are among the fastest-hydrating water soluble polymers available for the pharmaceutical market.
The resins are granular, white, free-flowing, hydrophilic powders supplied in a wide variety of viscosity grades corresponding to approximate molecular weight, offering exceptional formulating latitude. POLYOX™ extrudes particularly well and can easily be used in other types of heat treatments.
POLYOX™ is approved and marketed in drug products sold globally. The products have a long history of successful applications in uses such as controlled release solid dose matrix systems, oral osmotic delivery systems, tablet binding, drug delivery systems, and mucosal bioadhesives.
Applications for POLYOX™ Resins
POLYOX™ provides a viable alternative for use in matrices and osmotic systems due to its high swelling characteristics. The resins hydrate rapidly to form a gel layer on the tablet surface for the controlled release of APIs. Because POLYOX™ is non-ionic, no interaction between drug and polymers is to be expected. The fast hydration features of POLYOX™ allow gastro retentive systems to keep the dosage form in the stomach.
The thermoplasticity and gelling behavior of POLYOX™ makes it a successful candidate in discouraging and prohibiting abusers. POLYOX™ makes tablets extra tough to crush, or helps create a formula that can turn a tablet’s powdery contents into a gel-like substance when water is added. This prohibitsabusers from injecting the drug.
POLYOX™ polymers offers a number of important properties for mucoadhesion, including water solubility, hydrophilicity, high molecular weight, hydrogen bonding functionality, and good biocompatibility. Their long linear chain structure helps them to form a strong interpenetrating network with mucus. The polymer can be used in nasal solution applications.
POLYOX™ offers a number of important properties for mucoadhesion, including water solubility, hydrophilicity, high molecular weight, hydrogen bonding functionality, and good biocompatibility. The flexibility to penetrate the mucus membrane and hydrogen bonding groups make POLYOX™ resins effective for buccal and oral care.
Hot Melt Extrusion
POLYOX™ resins extrude extremely well and can easily be used in other types of heat treatments. Many abuse deterrent technologies take advantage of this property. Easy to use in conventional equipment, POLYOX™ also offers good flow characteristics. POLYOX™ has great film-making properties and can be used in a wide range of temperatures (230°F to 356°F).