A Versatile Ion Exchange Resin for Your Formation Needs
DUOLITE™ AP143 is a powdered ion exchange resin that can be used as an API for hypercholesterolemia solutions and as a formulation excipient in a variety of pharmaceutical applications.
DUOLITE™ AP143 resins have a broad range of applications, including taste masking, abuse deterrence, modified release and serving as excipients in the formulation of poorly soluble or unstable drug compounds.
DUOLITE™ AP143 has shown to be a safe and effective excipient and is currently found in many commercial drug formulations used throughout the world. The resins can be used for different types of oral dosage forms including solids such as tablets, capsules or liquid suspensions.
Applications for DUOLITE™ Ion Exchange Resins
DUOLITE™ AP143 resin used as an active pharmaceutical ingredient (API) can help lower a patient’s net cholesterol levels by capturing unwanted bile acids and preventing them from being re-absorbed by the body.
DUOLITE™ AP143 resins offer an exceptional solution to control the release of APIs in liquid suspensions and semi solids. The ion exchange resins can be used in combination with other excipients to provide targeted drug release profiles.
DUOLITE™ AP143 Ion Exchange Functional Excipients prevent bitter active ingredients from releasing in the mouth, which leads to better patient compliance.
In the case of poorly soluble ionizable drugs, the release of drug from a resinate can be faster than the rate of dissolution of the solid form of the drug. Hence, with DUOLITE™ AP143 resins, one can increase the rate at which poorly soluble drugs dissolve.
We believe that this rapid dissolution occurs because of two factors:
- Each individual drug molecule is bound to a functional site there is no crystal lattice energy to overcome.
- The ion exchange matrices are relatively hydrophilic and so allow water and aqueous solutions easy access into 3-dimensional structure – eliminating problems with “wetting out” the drug.
As a suitable tool for abuse deterrence, DUOLITE™ resins can bind the API and prevent immediate release event when the formulation is crushed. This maintains the intended rate of absorption.