CARBOWAX™ SENTRY™ PEGs and MPEGs
Versatility in API and Excipient Performance
CARBOWAX™ SENTRY™ Polyethylene Glycols (PEGs) and CARBOWAX™ SENTRY™ Methoxypolyethylene Glycols (MPEGs) are highly versatile excipients and APIs designed to address the exacting requirements of the pharmaceutical industry.
The products have 75 years of proven performance in a variety of formulations. As active pharmaceutical ingredients (APIs) their low toxicity is valuable in laxative and colonic lavage formulations. As excipients they are widely used in solid oral dosage forms, ointment formulation bases, gelatin capsules, liquid medications, and suppositories.
CARBOWAX™ SENTRY™ PEGs are available in a wide range of forms, viscosities and melting points, offering the flexibility to help optimize formulations.
Applications for CARBOWAX™ SENTRY™ PEGs and MPEGs
Used as APIs, CARBOWAX™ SENTRY™ PEGs are osmotic laxatives that can provide mild, effective relief without the common side effects seen in other laxative types. They are also widely used as colonic lavage to facilitate bowel cleansing prior to medical procedures.
CARBOWAX™ SENTRY™ PEGs and MPEGs are ingredients in liquid oral-dose medications such as cough medicines and elixirs, where they function as solubilizers and non-alcohol diluents.
CARBOWAX™ SENTRY™ products are also used extensively in soft gelatin capsules to enhance the solubility of the active substance as the primary water-soluble component in the liquid fill. For hard gelatin capsules, CARBOWAX™ SENTRY™ products effectively solubilize APIs in a melt-fill protocol.
CARBOWAX™ SENTRY™ PEGs act as binders and fillers that offer internal and external lubrication. In addition, CARBOWAX™ SENTRY™ PEGs are effective plasticizers in tablet coating formulations, providing good hardness, water solubility and lubricity. High molecular weights CARBOWAX™ SENTRY™ PEGs are also used to coat suppositories to provide elasticity and lubricity.
CARBOWAX™ SENTRY™ PEGs can be used in the synthesis of pharmaceutical actives such as diesters, carbonates, carbamates, and PEG/protein conjugates (‘PEGylation’).
Ointment Formulation Base
CARBOWAX™ SENTRY™ PEGs and MPEGS make excellent water-soluble ointment base, as they spread easily and evenly over the skin, even if moisture is present. PEG ointment bases effectively incorporate APIs but can be easily removed with water.