Application of QbD Principles to METHOCEL™ Extended Release Matrices
Controlled Release Alliance Partners, Colorcon and Dow Wolff Cellulosics, presented a new service for formulation design using QbD samples and process improvement tips for robust, extended release hypromellose matrices.
A case study on the influence of hydroxypropoxyl (HP) substitution, viscosity, and particle size, on performance of a hydrophilic matrix and the influence of inherent polymer variability, plus how to manage it, were discussed.
"Impact of Polymeric Excipient Selection and Process Variables on Hot Melt Extrusion"
*This podcast is provided by Pharmaceutical Technology
Presented by Mark Hall, Senior Application Development Specialist at Dow Wolff Cellulosics
Mark Hall is Lead Development Specialist within the Pharmaceutical Excipients R&D group of Dow Wolff Cellulosics. Mark's extensive background in polymer processing established Dow as a leader in Hot Melt Extrusion (HME) technology in the Pharmaceutical industry. He has 25 external papers/publications and seven issued patents. He joined Dow after receiving BS and MS degrees in Chemistry from Clarkson University. He is a member of the Controlled Release Society (CRS) and the American Association of Pharmaceutical Scientists (AAPS).