Technical Presentations

Following are the various technical papers presented by our Pharmaceutical technical team members at the American Association of Pharmaceutical Scientists (AAPS) and Controlled Release Society (CRS) conferences over the past several years.

2007

Evaluation of Formulations Produced via Hot Melt Extrusion that Contain High API Loading and Exhibit Controlled Release (9 KB PDF)

Castable Edible Pharmaceutical Films (9 KB PDF)

A New Hypromellose Excipient for Direct Compression Controlled Release Applications (9 KB PDF)

Foam-on-a-Spoon Drug Delivery: A New Technology for Liquid Medications (9 KB PDF)

2006

Foam Granulation Technology: Scale-up of Immediate Release and Controlled Release Formulations from Laboratory Scale to Manufacturing Scale (947 KB PDF)

Solubility Parameters as a Tool to Predict API Morphology in Hot Melt Extruded (HME) Formulations Containing Ethylcellulose, Hypromellose and Polyethylene Oxide (179 KB PDF)

Excipient Blends in Hot Melt Extrusions (151 KB PDF)

Film-Forming Polymers in Fast-Dissolve Oral Films (181 KB PDF)

A Re-examination of the Contributions of Diffusion and Polymer Erosion to Overall Drug Release from Hydrophilic Matrix Tablets (210 KB PDF)

Designed Studies on the Effects of Hypromellose Substitution Levels on Sustained Drug Release from Hydrophilic Matrix Tablets (780 KB PDF)

Hypromellose and Polyethylene Oxide Blends in Hot Melt Extrusion (491 KB PDF)

2005

Determination of Fast Dissolve Oral Film Dissolution Rate Via Conductivity (137 KB PDF)

Application of the Stationary Basket in the USP Type II Dissolution Apparatus (81 KB PDF)

Advantages of Foam Granulation and Process Miniaturization for Small Quantities of Micronized Drugs (156 KB PDF)

Modeling and Experimental Validation of Drug and Polymer Release from Hypromellose-Drug Compacts (625 KB PDF)

Application of QSPR to Modeling of Drug Release from Hypromellose-Drug Compacts (568 KB PDF)

2004

Thermal and Rheological Evaluation of Pharmaceutical Excipients for Hot Melt Extrusion (611 KB PDF)

Use of a Novel Foam Granulation Technique to Incorporate Low Drug Loading into Immediate Release Tablet Formulations (758 KB PDF)

Application of the "Sequential Layer" Model to Drug Release Profiles (187 KB PDF)

Foamed Aqueous Binders as Carriers of Low Dose Drugs (139 KB PDF)

Implementation of the "Sequential Layer" Controlled Release Model (179 KB PDF)

2003

Empirical Modeling of Tablets Containing Hypromellose (51 KB PDF)

Foam Technology: The Development if a Novel Technique for the Delivery of Aqueous Binder Systems in High-shear and Fluid-Bed Wet-Granulation Applications (309 KB PDF)

2002

A Study by Mixer Torque Rheometry (MTR) of the Interactions Between Hydroxypropyl Methylcellulose (Hypromellose) and Excipients (549 KB PDF)

Development of a Controlled Release Matrix Tablet Containing a Water-Soluble Drug Utilizing Hypromellose and Ethylcellulose (111 KB PDF)

Effect of Process Conditions on Various Sustained Release Formulations During Wet Granulation (2 MB PDF)

The Effect of Nozzle Type and Atomization Conditions on High-shear Granulation of a Sustained Release Formulation Containing HPMC (317 KB PDF)

2001

Development of a Compaction Process to Enhance Dissolution of Poorly Water-Soluble Drugs Utilizing Hypromellose† (771 KB PDF)

A Designed Study of Compression Parameters for a Sustained-Release Hydrophilic Matrix Tablet Formulation (469 KB PDF)

2000

Direct Compression of Sustained-release Hydrophilic Matrix Tablets Containing Hypromellose and MCC: Effects of a Lubricant (311 KB PDF)

Investigation of the Effect of Surface Area/Volume on Drug Release From Hypromellose Controlled Release Tablets (690 KB PDF)

Lab-Scale to Full Production Scale Evaluation of a Controlled Release Formulation Based on Hypromellose and Manufactured Using Roller Compaction Technology (489 KB PDF)

Direct Compression of Sustained-Release Hydrophilic Matrix Tablets Containing Hypromellose and MCC Part II: Effects of Silicified MCC Grades and a Glidant on Powder Flow (744 KB PDF)

The Utility of Hypromellose as a Porosity Modifier in an Ethylcellulose Compression Coating (223 KB PDF)

1999

A study of Polymer Blending and Polymer Erosion of Different Viscosity Grades of Hypromellose for Hydrophilic Matrix Tablets (440 KB PDF)

Solubility and Permeability Determination of Anhydrous Theophylline with Application to the Biopharmaceutics Classification System (316 KB PDF)

Direct Compression of Sustained-Release Hydrophilic Matrix Tablets Containing Hypromellose and MCC - Part I: Initial Powder Flow and Tablet Physical Properties with Lactose Filler (335 KB PDF)

Scale-up of a Controlled-Release Tablet Formulation Based on Hypromellose and Manufactured Using Roll Compaction Technology (373 KB PDF)

Influence of the Particle Size of the Inert Polymer in a Compression Coated Controlled Release Tablet (446 KB PDF)

1998

Polymer Erosion of Hydrophilic Matrices (238 KB PDF)

1997

Investigation into the Mechanical Behavior of Selected Pharmaceutical Polymer Excipients as Binding Agents in Roller Compaction (235 KB PDF)

Aqueous Granulation of an Ethylcellulose Containing Inert Matrix Formulation (264 KB PDF)

A Comparison Study of the Effect of Polymer Characteristics and Applied Coating Level on Controlled Release Matrix Systems (388 KB PDF)

The Effect of Dissolution Media on Drug Release from CR Tablets (138 KB PDF)

The Effect of Polymer Level, Polymer Viscosity, and Film Coating Level on a Controlled-Release Matrix Tablets (581 KB PDF)

Influence of Filler/Binder Composition on the Properties of an Inert Matrix Controlled Release System (79 KB PDF)

1996

Initial Evaluation of Selected Variables Affecting the "Robustness" of Matrix Controlled-Release Tablet Formulations Containing Hypromellose Polymers (780 KB PDF)

Evaluation of Granulation, Excipient Characteristics, and Drug Solubility in the Preparation of Hydrophilic Controlled-Release Matrix Tablets - CRS '96 (146 KB PDF)

1995

Effects of Dissoultion Media pH on Drug Release from Controlled-Release Matrix Tablets Containing Hypromellose and Acidic and Basic Additives - AAPS '95 (148 KB PDF)

Evaluation of the Use of METHOCEL in Fluid Bed Granulation As a Dry Binder AAPS '95 (127 KB PDF)

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^† Previously referred to as hydroxypropyl methylcellulose or HPMC

®™*Trademark of The Dow Chemical Company ("Dow") or an affiliated company of Dow.