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Literature Downloadable Literature on METHOCEL* Cellulose Ethers for Pharmaceutical Applications
Please select one of the following types of literature:
| General Literature |
Dow Pharmaceutical Excipients - An Expanding World of Solutions Through Science and Polymer Technology (231 KB PDF)
Overview pamphlet that describes the three families of Dow excipients for pharmaceutical applications: organically-soluble ETHOCEL™ Premium ethylcellulose, water-soluble METHOCEL™ Premium methylcellulose and hypromellose†, and POLYOX™ Water-Soluble Resins NF. This piece provides both specific application and functionality in use charts for our polymers in order to assist you in determining which product or products will meet your needs.
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Pharmaceutical Excipients from Dow Water Soluble Polymers (620 KB PDF)
Overview brochure that describes the three families of Dow excipients for pharmaceutical applications: organically-soluble ETHOCEL* Premium ethylcellulose, water-soluble METHOCEL Premium methylcellulose and hypromellose† , and POLYOX™ Water-Soluble Resins NF. Summarizes the major advantages of using these products in pharmaceutical formulations and provides a starting point for product selection. Includes information on the uses of these excipients in controlled release systems, tablet coating, granulation, extrusion, liquid preparations, and mucosal bioadhesives.
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METHOCEL Cellulose Ethers Technical Handbook (247 KB PDF)
A detailed overview of METHOCEL cellulose ethers. Includes information on general properties of METHOCEL products and their chemistry, descriptions of their many applications, and regulated uses. Provides in-depth information on preparation of aqueous solutions, powder form properties, solution properties, and film properties. Also covers the thermal gelation phenomenon, analytical methods, and handling considerations.
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| Application Specific Literature |
| Controlled Release |
Introducing METHOCEL™ DC Grade Hypromellose Polymers for Direct Compression of Controlled Release Dosage Forms (438 KB PDF)
Overview brochure that describes a direct compression (DC) Dow Wolff Cellulosics excipient for pharmaceutical applications: METHOCEL™ Premium DC Grade Hypromellose Polymers for Direct Compression of Controlled Release Dosage Forms. This is a water-soluble METHOCEL Premium methylcellulose that can eliminate the need for wet granulation and provides excellent tablet processing, physical properties, and dissolution profiles. The brochure summarizes the major technical advantages and lab data for two grades of this product in pharmaceutical formulations and provides a starting point for product selection. Includes direct comparisons to formulations containing METHOCEL Premium Controlled Release Grades.
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Using METHOCEL Cellulose Ethers for Controlled Release of Drugs in Hydrophilic Matrix Systems (2 MB PDF)
When METHOCEL Premium hypromellose† is used in controlled-release matrix systems, strong, fast-forming, highly viscous gels result. Here is a 32-page technical brochure that gives formulation guidelines and a detailed discussion of system variables and highly reliable polymer effects. These include solution viscosity and hydration rates, tablet dissolution, polymer-drug excipient interactions, effects of drug solubility, effect of pH…as well as other formulation and manufacturing considerations.
Japanese Version (2.2 MB PDF)
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| Supplements to above Controlled Release Brochure |
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Stability of Physical Properties and Drug Release of Controlled-Release Matrix Tablet Formulations Containing METHOCEL Cellulose Ethers (187 KB PDF)
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Roll Compaction Granulation of a Controlled Release Matrix Tablet Formulation Containing METHOCEL K4M Premium Ethers (276 KB PDF)
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| Granulation |
Use of DOW Cellulose Ethers in Granulation - Initial Recommendations (13 KB PDF)
This one-page chart offers you a starting point guideline in selecting the appropriate METHOCEL products for use in granulation applications.
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METHOCEL as a Granulation Binding Agent for Immediate-Release Tablet and Capsule Products (146 KB PDF)
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| Tablet Coating |
METHOCEL Premium in Aqueous Systems for Tablet Coating (289 KB PDF)
Versatile METHOCEL Premium cellulose ethers produce tough, printable, economical, and highly consistent tablet coatings whether they are aqueous, hydro-alcoholic, or solvent-based. This 28-page technical brochure gives an overview of METHOCEL Premium products for tablet coating, a brief review of the coating process and solvent systems, and coating formulation guidelines. Numerous charts present data on properties of tablet coatings produced with METHOCEL Premium polymers.
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† Previously referred to as hydroxypropyl methylcellulose or HPMC
®™*Trademark of The Dow Chemical Company ("Dow") or an affiliated company of Dow.
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