Dow Excipients

Liquid Preparations

METHOCEL* Premium products are used in oral and topical liquid pharmaceuticals because they are excellent thickeners and can be used to produce desired viscosity in liquid medications. They have thickening properties in both aqueous and organic solutions and may be used in hydroalcoholic systems.

ETHOCEL* Premium products provide the unique advantage of insolubility in water, but are soluble in organic solutions, so they can be used with water-sensitive materials.

The surfactancy properties of METHOCEL Premium cellulose ethers permit them to be used to improve stability. In products like liquid medications, METHOCEL Premium polymers act as a suspension agent. The water retention properties of METHOCEL Premium products are useful in bulk laxatives.

METHOCEL Premium products serve as demulcents in applications such as ophthalmic solutions. METHOCEL Premium cellulose ethers are used as a protective colloid and exhibit emulsification properties that benefit liquid formulations.

Cellulose ethers are good for suspending solids because they are efficient thickeners. They can be used to control rheology, modify water retention, or provide lubrication. Good viscosity stability within the pH range of 4 to 11 allows them to be used both with alkaline and acidic ingredients. They are fairly resistant to microorganisms and their film-forming properties are useful in topical applications.

Dow Excipients in Liquid Formulations
Application Products Recommended Typical Use Level Advantages
Bulk Laxatives METHOCEL A4M, K4M, K100M Premium 5 – 30%
  • High viscosities of METHOCEL K
    Premium hypromellose may prove more effective
Creams, Gels, and Ointments METHOCEL A4M,
E4M, F4M, K4M Premium

POLYOX WSR N-80 NF, WSR N-750 NF, WSR-205 NF
1 – 5%
Ophthalmic Preparations METHOCEL E4M Premium 0.1 – 0.5%
  • Best solution clarity; good lubricity at low concentrations
Suspensions METHOCEL A4M, E4M, K4M Premium 1 – 2%
Antacids METHOCEL A15C, A4M, E4M, K4M, K15M, F4M Premium 1 – 2%
  • Good suspension of solids; good microbial resistance


®™*Trademark of The Dow Chemical Company ("Dow") or an affiliated company of Dow.