Mucosal Bioadhesives

POLYOX™ Water-Soluble Resins, NF Grade offer important properties for mucoadhesion — water solubility, hydrophilicity, high molecular weight, hydrogen bonding functionality, and good biocompatibility. These resins have a long linear chain structure which allows them to form a strong interpenetrating network with mucus. Data indicate that molecular weights of 4,000,000 and higher have the highest level of adhesion.

Dow Excipients in Mucosal Bioadhesion

Application	Products Recommended	Typical Use Level	Advantages
Mucosal Bioadhesives	5 – 70%	5 – 70%	Strong mucosal interpenetration, good biocompatibility Excellent mucoadhesive and thickener

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